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Cover and simmer for 5 mins to finish cooking the chicken all the way through.įluff the rice with a fork and divide between two warm bowls. Stir fry for 1 min.Īdd any marinade left from the dish. Stir in the garlic, ginger and coriander stalks. Stir fry for 4-5 mins till the veg start to soften. Lift out of the pan and pop on a plate.Īdd the onion and peppers to the pan with 2 tbsp water. Stir fry for 5 mins till browned all over. Lift the chicken out of the marinade (keep the marinade for later). Gluten Free Paleo Whole30 This delicious Cashew Butter Chicken is as good as it gets. While the rice is cooking, put the wok back on the heat. Take off the heat and leave to steam in the pan for 5 mins to finish cooking it. Bring to the boil, then turn the heat down and simmer for 8 mins till the water has been absorbed. Finely chop the coriander stalks (keep the leaves for later).ĭrain the rice and rinse it under fresh cold water. Add the cashews and toast in the hot pan, shaking it occasionally, for 2-3 mins till the cashews are golden brown. Put a wok or deep frying pan over a medium heat. Cook about 30-seconds to one minute or until the cashews start to turn a golden brown. Heat your pan to medium-high heat and add your cashews and chile de arbol. In a separate bowl, stir together the tamari, 2 tbsp rice vinegar and 1 tbsp Demerara sugar (the sugar won't dissolve, so don't worry about that). In a small bowl, mix together your oyster sauce, thin soy sauce and water (or mushroom sauce and sugar if using the vegan version). Add 1 tbsp cornflour and stir to evenly coat. Put the diced chicken leg in a bowl or dish. Cover with cold water and set aside to soak. Chicken should be about 80-90 cooked through. To a large skillet, add the oils, chicken, and cook for about 4 to 5 minutes over medium-high heat, flipping and stirring so all sides cook evenly. I always enjoy any excuse to throw in extra veggies, for both nutritional reasons and appearances sake, so I loaded my version of this cashew chicken stir-fry with broccoli and bell peppers.Tip the rice into a bowl. Instructions To a gallon-sized ziptop bag, add the cornstarch, salt, pepper, chicken, seal, and shake to coat chicken evenly. *If you cannot find dry sherry you can try substituting it with hard apple cider, dry white wine, or vermouth in equal amounts.Īfter enjoying a plateful of this flavor-packed cashew chicken stir-fry, and licking it clean, I knew this recipe would have to be re-created in the near future. Fortunately, there is not too much brandy added and it can still be found in most of your local grocery stores. Sherry is a wine that has been fortified with brandy… simply meaning the brandy has been distilled with the wine. Sherry can come in sweet and dry varieties, as well as everything in-between. In the recipe below for this cashew chicken stir-fry, you will see that one of the main ingredients is dry sherry. Why had I not tried cooking with sherry before? And what exactly is dry sherry? She whipped out a bottle of dry sherry… I was immediately enthralled. When I arrived, Marissa was starting to prepare the cashew chicken. Toss the tofu around until the sauce is thickened. Turn the heat down and mix in the corn starch slurry. Because of the way that the tofu is coated in cornflour and then drenched in sauce, the texture. Step 6: Next, add in the sauce and the cooked tofu. And oh ya… some ah-maaaazing cashew chicken stir-fry was on the menu, too! Add in the garlic and the white pieces of the green onions. The perfect creamy soup for cold fall and winter days I know a bunch of people are going to ask me why I need to use 'chicken' in the title of this recipe. (My toenails ended up a brilliant shade of red thanks to Marissa’s toenail polish collection). Savory baked tofu, hearty veggies, and a rich cashew cream base go into this luscious vegan spin on cream of chicken soup. We had a night full of girly gab and painting toenails on the agenda. You might just want to lick your plate with this gluten-free and low-carb cashew chicken!Ī few weeks ago I had the pleasure of going to hang out with my awesome sista-in-law. Cashew Chicken Stir-Fry is loaded with healthy veggies, chicken, and a delicious stir-fry sauce. The cat sitting in his chair at the dining room table. My adult children flood the family group chat with memories and photos. How nice it would be to come home from work to a litter box full of cat shit. Since the cat’s diagnosis, I’ve spent most of my time researching enough cat-related medical information to qualify as a first-year veterinary resident. I stroke the cat’s back, hoping that the cat’s spinal column will send nerve impulses to contract the walls of his colon while I’m at work. 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When I put the plate in front of him, he gives me a sly smile, then licks the yellow squares into oblivion. I smile at the memory and cut three paper-thin slices from a cold stick of butter. He has stolen pancakes off my breakfast plate, just to get in a lick or two. We have three hours together before his last veterinarian appointment. It’s an embarrassing way to go out, he says. “I agree, my love,” I say, scratching him under his chin, tears running down my cheeks. They sound less like a complaint and more like a stoic acceptance of a hard truth. His meows now come in a much lower register. He looks at me and meows, but this meow does not sound like his typical sort of vocalization. Frustrated, he leaves the litter box and jumps up onto his favorite chair. The cat now teaches me that being tenacious at a fruitless task can quickly become a fool’s errand. Surely if he tries again, all will be well?īut the blockage in his system prevents him from excreting. The cat tries to defecate again, carefully scratching through the Fresh Step kitty litter as if it were a sand mandala. What happens when things that have always worked suddenly don’t? This puzzles him as he hasn’t been sick one day in his whole 15 years of life. God can take the blame for the rest.įor the hundredth time in a week, the cat valiantly tries to poop in his box and cannot. Redeem your Paw Points® for feline-focused rewards, or donate your Paw Points® to help your local cat shelterįor help setting up your Paw Points® Rewards account or to learn more about the program, visit the Fresh Step® website (.I have fed the cat butter and cream before he dies.ĭairy is terrible for a cat’s gastrointestinal tract, but then again, so is abnormal dilation of the colon. Earn even more Paw Points® with fun activities like adding a photo of your cat to your profile, putting favorite rewards on your Wishlist, adding a preferred cat shelter and moreĤ. Snap a picture of your Fresh Step® receipt and upload to add points, or enter codes from boxesģ. Sign up as a Paw Points® Rewards program member right from the app. Purr-worthy prizes: Enter to win the Fresh Step® Monthly Multi-Sweepstakesġ. Kitty funtime: Redeem Paw Points® for free kitty litter, cat toys, condos, coupons, and more - Share the love: Donate Paw Points® to your favorite cat shelter Make tracks: Keep track of your Paw Points® progress Scratch the surface: Browse the Rewards Catalog and add items to your Wishlist Cool as cats: Enter codes from purchases from anywhere-online or in stores-using your mobile device Feline fantastic: Upload a photo of your receipt to quickly enter your Paw Points® The Fresh Step® Paw Points® Rewards App makes it easy to earn points for all your Fresh Step® purchases and redeem them for cat litter, coupons, tantalizing cat toys, and even help for your favorite shelter. It’s located in one of the city’s oldest markets, Mercado de la Paz, and its tiny bar area is always packed with everyone from business professionals to blue-collar workers. Though located in one of the poshest neighborhoods of Madrid, Barrio Salamanca, Casa Dani is not at all pretentious. Or make your own at home with our tortilla de patatas recipe! Spanish food perfection! Where to Find the Best Tortilla in Madrid 1. Hungry for a tortilla yet? Satisfy your cravings and stop by the following spots for the best tortilla in Madrid. They enjoy their tortillas with a variety of ingredients, including peppers, tuna, and eggplants. Then there are the radical tortilla enthusiasts. Their opponents, the cebollistas (Team Onion) find this definition to be too narrow, and argue for the inclusion of onions in the dish. Diehard tortilla purists, known as sin cebollistas (Team No Onion), insist that a true tortilla de patatas should only contain eggs and potatoes. Spaniards’ love of the tortilla can get intense, and has incited many a tapas bar debate. Traditionally, tortillas in Spain are made with sliced potatoes. The word tortilla means “little cake” in Spanish, and a common English name for the dish is Spanish omelet. If you’re unfamiliar with Spanish cuisine, you may be picturing tacos right about now-but a Spanish tortilla is a nothing like the Mexican flatbread of the same name! You can’t use it to make a burrito (well, okay, you can try…but it would get really messy). Simply put, tortilla de patatas is the one dish you can’t come to Spain without trying. 3 Best Tortilla in Madrid FAQs What is a Tortilla de Patatas? Most of our Guests will benefit from the EPIC 4 or 7 Day Passes as they will save you a boat-load.Crested Butte Locals are purchasing EPIC Local Passes for the most part, but if you plan to ski more often at more resorts, go for the full monty and buy the EPIC Pass outright.The earliest and best pricing usually concludes in early September, then as we get closer to the ski season rates creek up until just on or before the mountains open. If you plan to ski at least 4 days at Crested Butte or any of the EPIC pass resorts then buy your EPIC Pass in advance.If you plan to ski less than 4 days, then order your lift tickets at least 7 days in advance.So how do you find the best lift ticket rates? In other words, the more folks who are skiing that day, or are expected to ski that day, will pay a higher daily rate. The catch? You need to plan ahead to receive the benefits of pass pricing discounts otherwise you are subject to daily yielding and window pricing! What does that mean anyway? It simply means that the ‘day of’ pricing is a factor of demand. First and foremost, the inclusion with other top resorts in North America and beyond is an amazing benefit if you like skiing in more than one destination per season or if you make multiple trips per year to ski, and or simply if you plan to ski more than 4 days at any one resort! The Rocky Mountain Chocolate Factory - This chocolate factory is located in Banff and it is known for its amazing chocolates.Since Vail Resorts acquired Crested Butte Mountain Resort, we’ve sifted through the changes with pass pricing and how the benefits will actually translate to Elk Mountain Lodge guests. Elk Mountain Lift Tickets - More Info Tuesdays starting Jan 4th Seniors 65+ get a 20 lift ticket. Lift Ticket Prices / Season Pass Prices Current prices not available. The Kicking Horse Coffee Company - This coffee company is located in Golden and it is known for its delicious coffee.ĥ. Contact Info / Directions back to main page Elk Mountain Lift Ticket Discounts No deals currently available, check back daily for new lift ticket specials. The Grizzly Paw Brewing Company - This brewery is located in Canmore and it is known for its amazing craft beers.Ĥ. The Elk Valley Grill - This grill is located in Fernie and it is known for its delicious burgers.ģ. SkiBig3 Lift Tickets and Season Pass provides access to three jaw-dropping resorts as well as exclusive pass perks with destination. The Elk Mountain Lodge - This restaurant is located inside the Elk Mountain Lodge and it offers a wide variety of dishes that are sure to satisfy everyone's taste buds.Ģ. There are also several beautiful lakes in the area that are perfect for swimming, canoeing, and kayaking.ġ. The best activities near Elk Mountain in British Columbia include hiking, fishing, and camping. Elk is a great place, and I would easily rate it as the best overall PA resort. If possible, I would highly recommend bringing your belongings in a backpack because there is a slope that can drop you off right in the parking lot for an easy out. We tried to buy our 12:30 pm tickets, but had to wait 20 min for them to go on sale since we arrived too early. Also, be aware that lift tickets for any time slots go on sale a half hour before hand. If you are going for the first time, be aware that there is a mini shuttle that takes you from the parking lot to the lodge/ticket booth. Registration Registration information will be. The trails were very well maintained and had much longer runs than many other comparable PA resorts. Package Includes Lift Ticket and Ski Rental for Members Snow Boards not included. The lift lines were ALL less than 5 min for the entire afternoon and evening. It certainly met my expectations as the crowds were very manageable (especially for a Saturday). 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Patients were enrolled regardless of tumor biomarker expression.įrom February 23, 2016, to August 03, 2016, 107 patients were enrolled at 42 sites in 16 countries (Supplementary Table S1). All patients were required to provide tumor tissue from a newly obtained core or excisional biopsy sample (preferred) or archival tumor sample of a nonirradiated lesion for PD-L1 assessment. Key eligibility criteria for the NET cohort included age ≥18 years well and moderately differentiated NET of the lung, appendix, small intestine, colon, rectum, or pancreas progression on or intolerance to ≥1 line of standard therapy measurable disease as assessed by Response Evaluation Criteria in Advanced Solid Tumors version 1.1 (RECIST v1.1) per independent central radiologic review Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 and adequate organ function. In brief, KEYNOTE-158 is an international, open-label, phase II study of single-agent pembrolizumab across multiple advanced solid tumor types that have progressed on standard-of-care systemic therapy. The study design of the KEYNOTE-158 clinical trial ( identifier: NCT02628067) has been described previously ( 21). Here, we present the results from the cohort of biomarker unselected patients with previously treated advanced well-differentiated NETs enrolled in KEYNOTE-158. The KEYNOTE-158 phase II basket study investigated the antitumor activity and safety of pembrolizumab monotherapy in multiple cancer types. Moreover, durations of response were 6.9, 9.2, and 11.1 months for the carcinoid responders and the pNET responder had an ongoing response of 17.6 months ( 20). Overall, three patients with carcinoid (12% 95% CI, 3%–31%) and one patient with pNETs (6% 95% CI, 0%–30%) had objective responses, and SD rates were 60% ( n = 15) and 88% ( n = 14), respectively ( 20). Single-agent pembrolizumab showed antitumor activity in some patients with previously treated, PD-L1–positive carcinoid and pNETs in the phase Ib KEYNOTE-028 study ( 20). One such immune checkpoint inhibitor is pembrolizumab, a highly selective, humanized mAb that blocks the interaction of PD-1 with its ligands, PD-L1 and PD-L2 ( 19). Immune checkpoint inhibitors have demonstrated antitumor activity in many tumor types. Furthermore, associations between higher PD-L1 expression and decreased survival have been reported in metastatic GEP-NETs and pulmonary NETs ( 14, 18). Similar associations between PD-L1 expression and tumor grade have been reported in metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NET ref. Consistent with these findings, expression of PD-L1 was rare among archival tissue samples from low-grade NETs of the small intestine ( n = 64) and pancreas ( n = 31 ref. Across NET sites, PD-L1 expression was detected in 0% of grade 1, 78% of grade 2, and 100% of grade 3 tumors ( 16). For example, PD-L1 expression was reported in 59% of pulmonary NETs ( 14) and 54% of insulinoma-like pancreatic NETs (pNET ref. Several studies suggest that programmed death ligand 1 (PD-L1) expression plays a role in the development, progression, and prognosis of NETs, especially in high-grade tumors. In cancer, PD-1 promotes tumor escape from host immune responses ( 12, 13). Programmed death 1 (PD-1) is a T-cell coinhibitory receptor that regulates immune response by interacting with its ligands (PD-L) ( 11). The piece features a remarkably humbling and melancholic melody yet an optimistic accompaniment, in the famous waltz rhythm, that conjure a variety of different emotions for each individual listener, making it one of the most popular pieces in the Classical repertoire to this day. Accompanied by Brahms’s regal Hungarian Dances, and Schubert’s vastly virtuosic Rondo for Violin, the evening is concluded with another classic, the immensely moving and hugely emotional Blue Danube Waltz, with its spacious and expansive opening. Join the orchestra as they explore the iconic moments of the Nutcracker through the wonder of the Arabian Dance, the delicacy of the Dance of the Sugar Plum Fairy and the romantic Waltz of the Flowers. With an evening, packed full of all your family favourites, the concert kicks off with the well-known elegance of Strauss’s Die Fledermaus Overture, before a selection of suites and highlights from Tchaikovsky festive ballets. With an enviable array of critical acclaim, a stunning selection of recordings on such prestigious labels as Chandos, Toccata Classics and Harmonia Mundi, and performances throughout the UK and Europe, London Concertante rightfully claims its position at the forefront of classical performers in the UK. The group has the rare ability to combine flexibility of instrumental grouping and consistently maintain superb artistic endeavour. London Concertante is one of the finest chamber ensembles in the country, its players brought together through a shared passion for chamber music. 08-12-2018 19:30 08-12-2018 21:30 36 Viennese Christmas by Candlelight Touring their ever-popular festive programme, London Concertante travel the length and breadth of the country presenting treats from across Europe to get you in the mood for mulled wine, mince pies, and baubles. Attempt to ventilate with 100% oxygen via laryngeal mask with cricoid force.Release cricoid force as laryngeal mask is inserted and reapply when inserted. If facemask inflation not possible, maintain 30 N cricoid force and insert laryngeal mask.If necessary use two hands to hold facemask and ask responder to squeeze bag. Insert oral airway and attempt facemask ventilation with 100% oxygen.Call for assistance and keep first responder.The only task now is to move to Plan C - the maintenance of oxygenation whilst the induction agent and muscle relaxation wear off and the patient awakens. There is no intubation Plan B because the patient is going to be woken up without any other attempts at intubation. Announce 'Failed intubation' to stop yourself carrying on with further attempts and to alert assistant that Plan A has failed.If intubation unsuccessful - stop further attempts.If difficult try alternative blade (long, straight, McCoy etc), bougie, and the limited amount of external laryngeal manipulation possible with cricoid force.30 N cricoid force (equivalent to registering 3 kg on a weighing machine) after loss of consciousness.Light pressure (no more than 10 N force) on the cricoid cartilage prior to loss of consciousness.Cricoid cartilage identified before induction by assistant.Adjust head/neck position prior to starting.(Please note that the quality of guideline image is low to aid fast loading. The scenario of a rapid sequence induction when surgery is immediately urgent (for example in extremis aortic aneurysm rupture) is not considered here in detail. In this case scenario, the urgency of the surgery is not immediate and failure of intubation activates a plan of 'wake-up' Airway evaluation is imperfect and so airway strategy must deal with unexpected difficult direct laryngoscopy and difficult facemask ventilation. Preoperative airway evaluation has not predicted any problem with airway management. The anaesthetic technique includes optimal preoxygenation, the use of an induction agent and suxamethonium, with the application of 30 N cricoid force at the onset of unconsciousness. This is a common anaesthetic technique in the UK when there is a risk of gastro-oesophageal reflux. This case scenario is of an adult, non-pregnant patient undergoing a rapid sequence induction. This guideline has now been superseeded by the 2015 intubation guidelines click here Rapid sequence induction, non-pregnant adult patient, no predicted difficulty |
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